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Southern Research Institute - Advanced Energy & Transportation Technologies (Durham) provides research and analytical services and facilities to government and commercial clients involved in energy, fuel and transportation technology development. ment-energy/north-carolina-operations- advanced-energy-and-transportation- technologies SOV Therapeutics Inc. (Morrisville) develops therapeutic treatments, with a focus on oral testosterone replacement therapies for adult men. SoyMeds Inc. (Davidson) is developing a seed-based expression platform that enables production of protein-based targets that can be used to diagnose and treat disease and address other unmet needs in the healthcare industry. Spirovation Inc. (Chapel Hill) is a specialty CRO with a focus on the development of breakthrough drugs in respiratory medicine. Sprout Pharmaceuticals Inc. (Raleigh) is developing a compound to treat hypoactive sexual desire disorder. Spyryx Biosciences Inc. (Chapel Hill) is developing disease-modifying therapies for obstructive lung disease based on the natural f uid control mechanism in the lung. The company's initial focus is on cystic f brosis. Sterigenics (Charlotte and Haw River) provides ethylene oxide sterilization for medical and pharmaceutical products at its EO facility in Charlotte. Sterigenics provides gamma radiation sterilization for medical and pharmaceutical products at its gamma facilities in Charlotte and Haw River. Stiefel, a GSK company (Research Triangle Park) develops prescription and OTC skin-care therapies. The company's primary research and development facility is in RTP. Structure Medical Inc. (Mooresville) is a contract manufacturer of orthopedic medical devices, including implantable orthopedic fracture f xation and spinal instrumentation products. Suncare Research Laboratories LLC (Winston-Salem) provides services to sunscreen and dermatological product manufacturers, including evaluation of sunscreen SPF and UVA protection. Surgilūm LLC (Wilmington) designs, manufactures and markets medical instruments for use in cataract and refractive surgery. Sustainable Ethanol Technologies LLC (Waxhaw) is commercializing low-cost, sustainable, cellulosic ethanol production. Symberix Inc. (Chapel Hill) researches enzymes produced by the microbiome to develop drugs that would improve the ef cacy of a range of therapeutics. Symmetry Biosciences Inc. (Research Triangle Park) provides contract research and specialized chemistry services to the biotech, pharmaceutical, medical device, agrochemical and f ne chemical industries. Synchrony Labs LLC (Durham) is an AAALAC- accredited large-animal, preclinical contract research organization. It provides preclinical testing services, specializing in models for safety, toxicology and ef cacy studies. Synereca Pharmaceuticals Inc. (Chapel Hill) develops orally active drugs that restore or increase the ef ectiveness of existing antibiotics. Syngenta Biotechnology Inc. (Research Triangle Park) works to increase plant yield by developing products for insect control and drought tolerance. Research Triangle Park is the company's central location for biofuels product development and includes the Advanced Crop Research Lab. Syngenta Crop Protection Inc. (Greensboro) develops and markets weed-, insect- and disease-control products. Synpac Inc. (Durham) is developing a drug for the treatment of Pompe disease. SynteractHCR Inc. (Morrisville) provides customized, full-service phase one through four clinical development services internationally across multiple therapeutic areas. Synthon Pharmaceuticals Inc. (Durham) develops and manufactures generics, as well as speciality pharmaceuticals and biosimilars in key therapeutic areas of oncology and multiple sclerosis. The Durham location is a regulatory of ce. Synthonix Inc. (Wake Forest) designs, manufactures and markets molecules to aid in drug discovery. T3D Therapeutics Inc. (Research Triangle Park) is developing and commercializing an oral therapy for diabetes and Alzheimer's disease. It has the potential to improve multiple Alzheimer's pathologies with one treatment. TAB Clinical Trials (Cary) provides global clinical trial support from pre-IND stage of development to postmarket approval for drugs and devices. TAB Clinical also provides drug safety and pharmacovigilance services. Tandem Labs Inc. (Durham) provides bioanalytical and immunoanalytical services, specializing in GLP-compliant LC/MS/MS bioanalytical services for all phases of drug discovery and development. Targacept Inc. (Winston-Salem) develops neuronal nicotinic receptors (NNRs) therapeutics for diseases and disorders of the nervous system. T3D's founder and CEO John Didsbury credits $300K in early NCBiotech loans for enabling his company's $1M in angel investment and recent $1.8M NIH Alzheimer's grant. Companies So – Tr North Carolina Bioscience Companies 32

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