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Nutrasorb NC LLC (Kannapolis) develops and markets a broad range of functionally- enhanced, high-quality ingredients with naturally-concentrated, stabilized, and bioavailable phytoactives from fruits and vegetables. Oak-Bark Corp. (Riegelwood) develops and manufactures semi-bulk and bulk chemicals, specializing in organosulfur products. Ocean Therapeutics Inc. (Cary) in-licenses, out-licenses and develops new medicines and drug candidates from marine organisms in a variety of therapeutic areas. Ocera Therapeutics Inc. (Durham) is a clinical-stage biopharmaceutical company focused on the development and commercialization of proprietary compounds to treat acute and chronic orphan liver diseases. Ocis Biotechnology Inc. (Wilmington) develops nanobiotechnology based on marine chemistries to repair, renew and regenerate extracellular matrix by stimulation of in vivo collagen production. Ocular Systems Inc. (Winston-Salem) provides corneal endothelial cells for transplantation, as well as related supplies and devices. It is an FDA-registered human tissue establishment. Oncoscope Inc. (Durham) develops optical imaging systems for guided biopsy of epithelial tissues in the esophagus, colon, lung, cervix and bladder. OncoTAb Inc. (Charlotte) develops and commercializes diagnostic blood tests designed to detect breast cancer. Oncotide Pharmaceuticals Inc. (Research Triangle Park) discovers and develops drugs that modulate protein phosphatases to disrupt cancer cells' ability to proliferate and survive. OnSite Remediation LLC (Cary) develops and uses naturally-occurring microbes, mechanical separators, coalescing units and f ltration systems for the removal of contaminants from water and soil. OpAns LLC (Durham) provides analytical services to support discovery, preclinical, toxicology and clinical studies. Oriel Therapeutics Inc. (Durham), a subsidiary of Sandoz, develops respiratory products as generic alternatives to patented drugs for asthma and COPD. It also develops and commercializes pre-metered unit and multi-dose dry powder delivery systems. OrthoMend Inc. (Wilmington) is developing a bio-absorbable polymer reinforced with nanodiamonds for bone f xation, and commercializes absorbable screws for drug delivery, bone growth and in vivo diagnostics in patients suf ering fractures and postsurgical trauma. Orthovative Technologies (Winston-Salem) has developed a nanotechnology-enabled device used to diagnose and minimize back pain. Osmotica Pharmaceutical Corp. (Wilmington) specializes in drug-delivery technologies and neurology-based therapies, including a treatment for Parkinson's disease. Ovation Biotech Inc. (Raleigh) produces renewable alkanes from recycled, waste and nonfood raw materials. Renewable alkanes are a direct replacement for petroleum alkanes, a primary ingredient in fuels and industrial products. Pace Analytical Services Inc. (Asheville and Raleigh) provides inorganic and aquatic toxicity testing services, as well as sampling services for groundwater, wastewater and soil at its laboratory in Asheville. The company's Raleigh laboratory provides environmental testing services specializing in bioassay, metals, wet chemistry, microbiology and organics. Panacea BioMatx Inc. (Morrisville) creates and sells customized nutritional supplement formulas in personalized gel-packs. PAREXEL International Corp. (Durham) provides drug-development and launch services, including clinical development, integrated advanced technologies, regulatory af airs consulting and commercialization services. Parion Sciences Inc. (Durham) develops therapies to treat defects of the innate mucosal defense system in respiratory and ophthalmology diseases. Patheon (Durham and Greenville) provides contract development and commercial manufacturing services for a full array of solid and sterile dosage forms, including small- molecule API and biologic drug substances. Patheon's Greenville site manufactures sterile injectables (liquid and freeze-dried) and solid-dose tablets and capsules. Pathf nder Pharmaceuticals Inc. (Durham) specializes in early stage drug discovery, with a focus on cancer therapy. www.pathf Patrin Pharma Inc. (Salisbury) develops pharmaceutical products, primarily oral dosage forms for gastrointestinal, cardiovascular, antiviral, antibacterial and central nervous system indications. Pearl Therapeutics Inc. (Durham), a subsidiary of AstraZeneca, develops combination therapies and formulations of inhaled drugs for chronic respiratory diseases such as asthma and COPD. Peptagen Inc. (Raleigh) develops nasally- administered cytotoxic T-lymphocyte nanoparticle vaccines for the prevention and treatment of pathogenic diseases and cancer, with a lead program in treatment of HIV/ AIDS-related illness. North Carolina Bioscience Companies 27 Companies Pf – Pr

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