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HRF Inc. (Raleigh) is a plasma center that provides human blood plasmas for bioscience research. www.hrf Humacyte Inc. (Morrisville) develops processes to engineer human tissue scaf olds that can be shaped into tubes, sheets or particulates for regenerative medicine uses. The current product focus includes vascular disease, therapeutic f lling and soft-tissue repair. Hydro Service and Supplies Inc. (Durham) provides design, manufacturing and installation of high-purity water systems for laboratory and manufacturing processes. It also provides microbiological and enzymatic water testing services. Hyperbranch Medical Technology Inc. (Durham) is a biosurgical device company focused on the design, development and manufacture of resorbable surgical sealants for general and specialty surgery use. ICON Clinical Research (Durham) provides drug development and clinical services, from compound selection to phase one through four clinical studies, in areas including oncology, cardiovascular and biosimilars. IDEXX Reference Laboratories Inc. (Greensboro) provides animal health diagnostic products and services for use in small animals, equine, poultry and dairy livestock. It also provides microbiology-based water testing products. Idyllic Pharmaceuticals LLC (Cary) is a drug development company that in-licenses products that have already entered clinical trials, develops drugs to a more advanced stage and out-licenses them for commercialization. ILS Genomics LLC (Research Triangle Park) provides genotyping, gene expression analysis and biologics product safety testing services. ImmunogeniX LLC (Asheville) provides a cryonics biorepository for storage of patient tumor cell samples, with the goal of using those cells in tumor vaccine immunology. ImmunoReagents Inc. (Raleigh) manufactures primary and secondary polyclonal antibodies used in research and in vitro diagnostics for the pharmaceutical and veterinary markets. Inanovate Inc. (Durham) develops nanostructured biochip substrates for high-throughput protein screening and analysis. The company also provides a variety of microarray services such as protein printing/ arraying and assay development. INC Research Inc. (Raleigh and Wilmington) provides phase one through four contract research services across a variety of therapeutic areas, with the capability to work with special populations, such as women and children. Indexus Biomedical LLC (Morrisville) designs, develops and manufactures instrument systems, reagents and assays for in vitro diagnostics, initially focusing on the hematology and immunology markets. Indicus Pharma LLC (Raleigh) develops generic formulations in oral solid dosage forms, parenterals and ophthalmics. Products are manufactured at a partner facility in India. Ingredion Inc. (Winston Salem) manufactures sweeteners and starches from corn. InnaVasc Medical Inc. (Research Triangle Park) designs and develops products for vascular access. The compay's f rst technology is a production method that modif es existing synthetic vascular graft for immediate hemodialysis access and the prevention of back-wall needle punctures. Innocrin Pharmaceuticals Inc. (Durham) discovers and develops a novel small molecule CYP17 lyase inhibitor that can be taken orally to treat castration-resistant prostate cancer. Innovate Biopharmaceuticals (Raleigh) is developing a novel medicine with a dual mechanism for ulcerative colitis and inf ammatory bowel disorders and a synthetic hormone to assist in the diagnosis of pancreatitis. Innovative Neurophysiology Inc. (Durham) designs and develops advanced tools, equipment and methodology for neuroscience research. InoLife Technologies Inc. (Raleigh) develops personalized medicine services and genetic testing for biomarkers including DNA testing for paternity and ancestral origin, response to Plavix medication and predisposition to certain diseases. Integrated Laboratory Systems Inc. (Morrisville) provides GLP toxicology, histopathology, molecular biology, and research and development services to government and commercial clients in agro-chemical, biopharmaceutical and environmental industries. Intelligent Implant Systems LLC (Charlotte) designs and develops medical devices for the spine. inVentiv Health Clinical (Cary) provides global drug development services to pharmaceutical, biotechnology, generic drug and medical device companies. Invitrox Inc. (Research Triangle Park) develops specialty disease diagnostics and therapeutic monitoring assays using the characteristics of microparticles to detect early signs of cellular damage. Every dollar NCBiotech loans to a young life science company is met by an average $118 in additional funding: government contracts and grants, equity investors, public stock sales. Companies Hr – Ke North Carolina Bioscience Companies 20

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