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BotaniPharm LLC (Candler) develops botanical medicines using biologically standardized, forest-grown goldenseal. Brite Bio Inc. (Research Triangle Park) provides contract research services, such as cell culture services, cell-based assays, biomarker assay development and gene expression prof ling and characterization. Burke Research Associates LLC (Morganton) conducts phase three and four clinical trials for gastrointestinal disorders such as ulcerative colitis, Crohn's disease and diverticulitis. Burleson Research Technologies Inc. (Morrisville) provides laboratory services to the biotechnology, pharmaceutical, chemical manufacturing and health care industries with proof-of-concept, preclinical, clinical and toxicology studies. C Change Surgical LLC (Winston-Salem) researches, patents and commercializes surgical technologies, with a focus on computerized, therapeutic temperature management technologies. Calvert Laboratories Inc. (Cary) provides preclinical research and contract drug discovery and development services, such as lead identif cation and lead optimization services. Camargo Pharmaceutical Services LLC (Durham) provides contract drug development services, including formulation and testing, regulatory consulting and phase one through four program development. Camras Vision Inc. (Research Triangle Park) is developing a medical device to treat glaucoma. Cancer Advances Inc. (Durham), a subsidiary of Cato Bioventures, develops therapeutics to treat gastrointestinal cancers. Capture Pharmaceuticals Inc. (Chapel Hill) develops oral and topical formulations of diethylenetriaminepentaacetic acid prodrugs as radionuclide decorporation agents. CardioPharma Inc. ( Wilmington) develops combinatorial products to treat cardiovascular disease. Cardioxyl Pharmaceuticals Inc. (Chapel Hill) develops therapies for cardiovascular disease using nitroxyl technology. Carolina BioPharm Inc. (Raleigh) develops small-molecule cancer treatments. Carolina Immunochemistry LLC ( Winston Salem) develops immunological reagents and homogenous assays for vitamin D and drugs of abuse that can be run with equipment already present in most physician laboratories. Carolina Liquid Chemistries Corp. ( Winston-Salem) is a medical device company specializing in diagnostic tests for physician, hospital and reference laboratories. Carolina Research Institute for Infectious Disease Inc. (Research Triangle Park) is an independent, nonprof t research organization that identif es and optimizes new classes of antibiotics. Carolinas HealthCare System Division of Therapeutic Research and Development (Charlotte) conducts clinical studies, patient-focused translational research and outcomes research. and-clinical-trials XELLIA Companies Ce – Ch 10 North Carolina Bioscience Companies

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