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BioShape Solutions Inc. (Durham) develops medical devices that deliver antibiotics to prevent and treat orthopedic implant infections. Biospecimen Procurement Solutions Inc. (Chapel Hill) provides devices for the acquisition, cryopreservation and transport of human tissue specimens (biospecimens) used in biomarker analysis. BPS is the research and development subsidiary of Core Prognostex Inc. Biotech Restorations LLC (Denver) provides bioremediation of petroleum and chlorinated hydrocarbons, especially gasoline and diesel and organochloride pesticides, PCBs and volatile chemicals. BioTrackers Inc. (Charlotte) develops bacterial, or microbial, source tracking technology. Bio-Val LLC (Cornelius) provides assay development, method validation, regulatory compliance and medical writing services. BioVendor LLC (Asheville) sells biological reagents and research products, including enzyme-linked immunosorbent assay (ELISA) kits, antibodies, proteins and other molecules for life sciences research. The Asheville site is the U.S. headquarters. Bioventus LLC (Durham) researches and develops biomaterials, cell-based therapies and other products to treat osteoarthritis and orthopedic injuries, as well as related infections and pain. BioZyme Inc. (Apex) develops and sells substrates for metalloproteinases (MMPs and ADAMs) which can be used in enzyme assays and other diagnostic tests. BioZyme also provides contract enzymology services such as inhibitor screening. Blue Ridge Institute for Medical Research (Horse Shoe) researches protein kinase enzymes and targeted cancer therapies. Botanics Integrated LLC (Durham) researches botanical extracts and develops botanical medicines to treat cardiovascular diseases. North Carolina has more than 600 life science companies statewide: 105 of them in production and manufacturing, 128 in contract research and testing, 363 in R&D and nine others in specialized categories. North Carolina Bioscience Companies 9 Companies 1 – Ar

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