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Companies Ar – Be Ardeal Pharma Inc. (Brevard) is developing stabilized sulforaphane for the dermal pharmaceutical and cosmetic markets. Argos Therapeutics Inc. (Durham) develops immunotherapy treatments for cancer, HIV and autoimmune disorders. Array BioPharma Inc. (Morrisville) develops targeted, small-molecule drugs to treat cancer and infammatory diseases. ArrayXpress Inc. (Raleigh) applies bioinformatics to optimize bioprocesses, increase diagnostic efciency and provide contract research services, focusing on next generation genomics. Arysta LifeScience North America LLC (Cary) develops and manufactures crop protection products. Ascletis Inc. (Chapel Hill) discovers and develops treatments for cancer, HIV and HCV. Asinex (Winston-Salem) designs smallmolecule libraries and provides lead optimization, custom synthesis and other chemistry services. The Winston-Salem location is the company's U.S. headquarters. Asklepios Biopharmaceutical Inc. (Chapel Hill) develops protein- and cellular-based therapies using a proprietary technology platform called Biological Nano Particles (BNP). Asymchem Laboratories (Morrisville) provides contract chemical- and drugmanufacturing services. Asymchem's administrative headquarters is in North Carolina and its manufacturing plants are in China. ATEX Technologies Inc. (Pinebluf) designs, develops and manufactures medical textiles and component solutions for the medical industry. 4 North Carolina Companies Attagene Inc. (Morrisville) has developed a pathway profling technology to evaluate the impact of pharmaceuticals and environmental chemicals on over 100 transcription factors and 48 nuclear receptors. Avioq Inc. (Research Triangle Park) develops, manufactures and distributes diagnostic assays and equipment for the detection of infectious diseases. FDA-approved products include screening and diagnostic assays for HIV-1 and HTLV-I/II. Aviria Biosciences Inc. (Durham) combines novel compounds and FDA-approved drugs in an efort to develop an adjuvant therapeutic that will promote viral eradication to cure HIV. Avoca Inc. (Merry Hill) develops and manufactures botanical extraction products and provides extraction services. Avoca also contracts with farmers to grow clary sage. divisions/avoca b3bio Inc. (Research Triangle Park) develops RNA oligonucleotide-based drugs to treat cancer, infammation and infection. Banner Pharmacaps Inc. (High Point) researches, develops and produces gelatinbased oral dosage pharmaceutical products. BaseTrace (Research Triangle Park) develops DNA-based tracers for hydraulic fracturing to analyze groundwater. BASF Corp. (Research Triangle Park) researches and develops plant-health products such as fungicides, insecticides and herbicides. The RTP site represents the company's Crop Protection Chemicals business. BASF Plant Science (Research Triangle Park) conducts plant biotechnology research and develops agricultural products through its gene discovery platform, focusing on yield and quality traits in crops such as corn, soybean and rice. Baxano Surgical Inc. (Raleigh and Wilmington) designs, develops and markets minimally invasive surgical technologies and devices to treat degenerative conditions of the spine. Baxter Healthcare Corp. (Marion) produces intravenous and peritoneal dialysis solutions, as well as empty containers and component parts for other Baxter facilities. Bayer CropScience LP (Research Triangle Park, Morrisville and Clayton) uses the tools of plant biotechnology to develop seeds and products for crop protection and nonagricultural pest control. The company's R&D Innovation Center and BioAnalytics and Regulatory Afairs operations are in Morrisville. The Clayton site performs pesticide research, specifcally in turfgrasses and ornamentals. BD Diagnostics (Burlington, Durham and Mebane) develops and commercializes molecular diagnostic products for various cancers, including cervical, breast, ovarian and prostate. BD Medical (Wilson) manufactures medical devices and injection- and infusion-based drug-delivery products. BD Technologies (Research Triangle Park) develops technologies for parenteral drug delivery, diabetes care, diagnostics and biosensors, and cell and tissue engineering. The RTP site is BD's Corporate Technology R&D center. Benson Hill Biosystems Inc. (Research Triangle Park) develops technologies to enhance yield in crop plants by improving the metabolic processes associated with photosynthesis. NCBiotech has awarded more than $22.2 million in small-company loans, which have been leveraged into more than $2.6 billion in additional funding.

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