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Companies No – Os Novo Nordisk Pharmaceutical Industries Inc. (Clayton) manufactures insulin products and pre-flled insulin delivery devices. Novolipid Inc. (Research Triangle Park) modifes known drugs by appending a proprietary labile fatty acid to create NCE conjugates with a high afnity for albumin. Its initial focus is in oncology applications. Novozymes North America Inc. (Franklinton) manufactures industrial enzymes, microorganisms and biopharmaceutical ingredients, which are used in more than 30 industries, including aquaculture, baking, biofuels, brewing, detergents, food products and textiles. NPBiosciences LLC (Research Triangle Park) develops platforms based on humanized mice to accelerate discovery and development of novel therapies. Nufarm Americas Inc. (Morrisville) manufactures and markets insecticides, fungicides, plant growth regulators and herbicides. This site serves as Nufarm's primary R&D facility in the United States. Nutra-Pharma Manufacturing Corp. of N.C. (Lexington) manufactures vitamins, supplements and other wellness products. Nutrasearch LLC (Research Triangle Park) provides contract research on the efects of foods and food ingredients on disease and pre-disease conditions, such as obesity, diabetes and high blood pressure. Nutrasearch also distributes human primary cells and cell-based products. Nutrasorb NC LLC (Kannapolis) develops functional foods, dietary supplements and cosmetic ingredients using naturally concentrated phytonutrients such as anthocyanins from fruits and vegetables. Oak-Bark Corp. (Riegelwood and Wilmington) develops and manufactures semi-bulk and bulk chemicals, specializing in organosulfur products. The production facility is located in Riegelwood and the corporate ofce is located in Wilmington. Ocean Therapeutics Inc. (Cary) in-licenses, out-licenses and develops new medicines and drug candidates from marine organisms in a variety of therapeutic areas. Ockham (Cary) provides full clinical research management to biotechnology and pharmaceutical organizations for their oncology trials. Ockham also provides strategic consulting in preclinical and clinical development. Ocular Systems Inc. (Winston-Salem) provides corneal endothelial cells for transplantation, as well as related supplies and devices. It is an FDA-registered human tissue establishment. Oncoscope Inc. (Durham) develops optical imaging systems for guided biopsy of epithelial tissues in the esophagus, colon, lung, cervix and bladder. Oncotide Pharmaceuticals Inc. (Research Triangle Park) discovers and develops drugs that modulate protein phosphatases to disrupt cancer cells' ability to proliferate and survive. OpAns LLC (Durham) provides analytical services to support discovery, preclinical, toxicology and clinical studies. Oriel Therapeutics Inc. (Durham), a subsidiary of Sandoz, develops respiratory products as generic alternatives to patented drugs for asthma and COPD. It also develops and commercializes premetered unit and multidose dry powder delivery systems. Oryx Bio Inc. (Raleigh) Bio develops biosensors and bioseparation products for use in bioanalysis research and biopharmaceutical production. Scc AvocA Inc. Osmotica Pharmaceutical Corp. (Wilmington) specializes in drug-delivery technologies and neurology-based therapies including a treatment for Parkinson's disease. 24 North Carolina Companies

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