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Companies In – Ke Inanovate Inc. (Durham) develops nanostructured biochip substrates for highthroughput protein screening and analysis. The company also provides a variety of microarray services such as protein printing/ arraying and assay development. Integrated Laboratory Systems Inc. (Morrisville) provides GLP toxicology, histopathology, molecular biology, and R&D services to government and commercial clients in agrochemical, biopharmaceutical and environmental industries. Jenken Biosciences Inc. (Research Triangle Park) researches and develops small-molecule TLR-4 antagonists for potential treatment of infammation associated with chronic liver disease, infammatory bowel disease, diabetes and organ damage. INC Research Inc. (Raleigh and Wilmington) provides Phase I-IV contract research services across a variety of therapeutic areas, with the capability to work with special populations such as women and pediatrics. Intelligent Implant Systems LLC (Charlotte) designs and develops medical devices for the spine. JLA International Inc. (Edenton) provides testing and analytical services for the food and beverage industry. It also provides technical consulting services. Indicus Pharma LLC (Raleigh) develops and manufactures generic formulations in oral solid dosage forms, parenterals and ophthalmics. Ingredion Inc. (Winston-Salem) manufactures sweeteners and starches from corn. Innovative Energy Solutions LLC (Franklin) manufactures specialty polymer coatings infused with an FDA-approved biocide, silver chloride. The coatings are used in health care and other commercial settings as a surface antimicrobial. Innovative Neurophysiology Inc. (Durham) designs and develops advanced tools, equipment and methodology for neuroscience research. InoLife Technologies Inc. (Raleigh) develops personalized medicine services and genetic testing for biomarkers including DNA testing for paternity and ancestral origin, response to Plavix medication and predisposition to certain diseases. Intrexon Corp.'s (Research Triangle Park) AgBio division facilitates production of enhanced food, as well as proteins and ingredients produced in agricultural-based expression systems. Jubilant Clinsys Inc. (Raleigh) provides clinical research services in support of Phase I-IV drug development. inVentiv Health Clinical (Cary) provides global drug development services to pharmaceutical, biotechnology, generic drug and medical device companies. K BioPharma LLC (Cary) develops and commercializes clinical-stage therapeutics for the treatment of anxiety and stress related disorders, peripheral neuropathy, Alzheimer's disease, mild cognitive impairment, multiple sclerosis-induced spasticity and glaucoma. Invitrox Inc. (Research Triangle Park) develops specialty disease diagnostics and therapeutic monitoring assays using the characteristics of microparticles to detect early signs of cellular damage. KaryoLogic Inc. (Durham) provides chromosome analysis services, such as karyotyping of human, rat and mouse cell lines, to research laboratories. Ironwood Material Science Inc. (Hurdle Mills) develops biomaterials for use as bone cement and synthetic bone in dental and orthopedic applications. Katharos Inc. (Apex) is developing a phosphateselective adsorption blood fltering medical device to treat high blood phosphate levels in end-stage renal disease hemodialysis patients. JABB of the Carolinas Inc. (Pine Level) develops and manufactures fungal pesticides and biopesticide products. Products are distributed through its partner company, Terregena. KBI Biopharma Inc. (Durham) provides contract development and biopharmaceutical manufacturing services such as formulation, analytical method development, stability services, process development and API manufacturing. EduCATIoNAL ASSISTANCE Southeastern and eastern North Carolina's numerous academic research facilities are using the tools of marine biotechnology, agricultural biotechnology and biomanufacturing to fnd new crops, new medicines and new opportunities for producing biofuels. 18 North Carolina Companies Kenactiv Innovations Inc. (Snow Hill) develops and manufactures bio-based fber products from kenaf. KeraNetics LLC (Winston-Salem) develops and commercializes keratin-based biomaterials for therapeutic and regenerative medical applications.

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