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Companies Dh – En DSM Pharmaceuticals Inc. (Greenville) manufactures sterile injectables (liquid and freeze-dried), solid dose (tablets and capsules), semi-solid (creams and ointments) and liquid products. Ei, A Pharmaceutical SolutionWorks (Kannapolis) develops and manufactures liquid, semisolid and powder prescription and non-prescription skin-care and animal-health products. Duke Clinical Research Institute (Durham) is an academic clinical research organization that conducts clinical research projects from pilot study to global trials, device trials to outcomes analyses. Eisai Inc. (Research Triangle Park) discovers, develops and markets pharmaceuticals in three main therapeutic areas — neurology, gastrointestinal disorders and oncology/critical care. Eisai's RTP facility does pharmaceutical production and formulation R&D. Novartis DuPont Pioneer Center for Dryland Research - Coastal Plains (Kinston) conducts research on the conventional and transgenic development of corn, soybeans and other crops, with an emphasis on drought-resistant products. Dharma Laboratories LLC (Morrisville) develops dosage forms, including oral solids, liquids, injectables, topicals and specialty products. DNA:SI Labs (Burlington) provides forensic DNA and identity testing services to lawenforcement and other government agencies. Dole Nutrition Research Laboratory (Kannapolis) conducts research on phytochemicals found in fruits and vegetables. Drumetix Laboratories LLC (Greensboro) provides bioanalytical support for drug metabolism, pharamcokinetics and toxicokinetic (DMPK, ADME) studies, as well as LC-MS/MS analysis of smallmolecule biomarkers, such as neurotransmitters, all-trans retinoic acid and creatinine. 12 North Carolina Companies Dyadic International Inc. (Greensboro) discovers, develops and manufactures proteins, enzymes, polypeptides and small molecules for use in the animal nutrition, detergent, ethanol, pulp and paper, biopharmaceutical, starch and textile markets. Eboo Pharmaceuticals Inc. (Durham) develops small-molecule drugs targeted at the opioid receptor family to treat Parkinson's disease, depression and other disorders. Ecoblend LLC (Pittsboro) develops and manufactures organic weed- and pest-control products, using soy methyl esters as a main ingredient. Efpharma Inc. (Chapel Hill) discovers and develops therapeutics to treat disorders of the central nervous system, with a particular focus on Parkinson's disease, Alzheimer's disease and other cognitive impairments, and schizophrenia. Efux Biosystems LLC (Morrisville) provides contract research services, particularly genitourinary and gastrointestinal tract preclinical drug discovery services, to pharmaceutical, biotech and academic research organizations. EMSL Analytical Inc. (Morrisville, Charlotte and Kernersville) provides analytical services, including microbiology, asbestos, indoor air quality and food testing. EN-CAS Analytical Laboratories (WinstonSalem) provides GLP-compliant analytical chemistry contract services for agrochemical, veterinary and bioanalytical research. EN-CAS has experience with preclinical and clinical trials support, pesticides, herbicides and veterinary drugs. Enci Therapeutics Inc. (Research Triangle Park) ENCI is developing monoclonal antibody-based therapeutics to treat breast cancer. ENCO Pharmaceutical Development Inc. (Cary) is a cGMP-compliant contract testing laboratory, with analytical development services ranging from raw-materials testing through Phase III stability studies and release testing as well as formulation-development services. Endacea Inc. (Research Triangle Park) develops A1 adenosine receptor antagonists as drug candidates for infammation, including sepsis and asthma, and renal impairment. A subsidiary of the company, Endacea Diagnostics, is developing an HTRF endotoxin assay as a sensitive and specifc biomarker for sepsis.

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